Bioacoustics Research Lab
University of Illinois at Urbana-Champaign | Department of Electrical and Computer Engineering | Department of Bioengineering
Department of Statistics | Coordinated Science Laboratory | Beckman Institute | Food Science and Human Nutrition | Division of Nutritional Sciences | College of Engineering
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William D. O'Brien, Jr. publications:

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Your search for ultrasound produced 3296 results.

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Title Focal chorioretinitis produced by ultrasound.
Author Purnell EW, Sokollu A, Torchia R, Taner N.
Journal Invest Ophthalmol Vis Sci
Volume
Year 1964
Abstract Two hundred and forty rabbit eyes were exposed to focused ultrasonic radiation at either 3.5 mc. or 7 mc. Circumscribed chorioretinal lesion and localized destruction of the ciliary body could be obtained without evidence of injury to other ocular tissues. The sound beam retrodisplaces detached retinas. These observation suggest possible uses of ultrasound in retinal detachment repair, cyclodiathermy, and destruction of intraocular tumor.


Title Focal destruction of nervous tissue by focused ultrasound: Biophysical factors influencing its application.
Author Ballantine HT Jr, Hueter TF, Nauta WJH, Sosa DM.
Journal J Exp Med
Volume
Year 1956
Abstract It has recently been established (1-3) that focused ultrasound can produce discrete areas of tissue damage deep within brains of cats and monkeys. Such lesions have a great potential value for the neurophysiologist, and ultrasonic techniques may well have a place in the treatment of diseases of the human nervous system. In order to realize this potential, however, certain rigid criteria must be met. First, damage must be limited to the region selected for destruction. Second, this region must be rendered completely non-functional in a large percentage of cases. Third, the extent of the zone of destruction following any given irradiation dose must be predictable. The investigations to be reported here were designed to identify some of the biophysical factors which must be controlled if these criteria are to be satisfied.


Title Focal lesions in the brain of growing rabbits produced by focused ultrasound.
Author Young GF, Lele PP.
Journal Exp Neurol
Volume
Year 1964
Abstract Trackless focal lesions could be placed at preselected sites within the brain of rabbits at various stages of development by irradiation with a single beam of focused ultrasound. Similar lesions could also be made in the fetal rabbits in situ at gestational age of 24 days. The histological characteristics and evolution of ultrasonic lesions, studied during 2 months after irradiation, did not differ significantly regardless of the age at operation (1 day to adult), and they were similar in all respects to lesions similarly produced in the brain of the adult cat.


Title Focused ultrasound as a stimulator of the nerve structures.
Author Gavrilov LR.
Journal Arch Acoust
Volume
Year 1984
Abstract Pulsed focused ultrasound can stimulate the receptor and conductive nerve structures of man and animals, as well as neurons of the central nervous system of the invertebrates. The possibility of a wide practical use of this method in medicine and physiology is considered. For example, the stimulating ability of focused ultrasound is applied for neurological disease diagnosis, to study skin and tissue sensitivity of man, to diagnose hearing disorders and to introduce auditory information to the deaf with certain forms of hearing pathology. The effecting factors of focused ultrasound as a stimulus for nerve structures irritation are discussed.


Title Focused ultrasound treatment of cervical lymph nodes in rats with EAE: A pilot study
Author Podkowa A, Miller RJ, Motl RW, Fish R, Oelze ML.
Journal Ultrasound in Med. & Biol.
Volume
Year 2016
Abstract In this pilot study, focused ultrasound (FUS) was used to produce hyperthermia in cervical lymph nodes of rats having experimental autoimmune encephalomyelitis (EAE) to alleviate symptoms associated with EAE. EAE was induced in dark agouti rats, and EAE scores were recorded over 21 d. At the onset of EAE symptoms, rats were treated with FUS to induce temperatures of 43–44C for 20 min in the superficial cervical lymph nodes. An EAE remittance score was tallied for all rats, defined as the maximum EAE score observed minus the minimum EAE score observed after the maximum EAE was reached. On average, the peak remittance score for FUS-treated rats was 1.14 ± 0.48 versus 0.33 ± 0.27 for sham-treated rats. These differences were statistically significant (p 5 0.037). Therefore, FUS treatment of cervical lymph nodes in rats with EAE resulted in a significant reduction in EAE score.


Title Focusing and scanning of ultrasound by spatial amplitude modulation.
Author Noorbehesht B.
Journal Proc IEEE
Volume
Year 1983
Abstract Spatial amplitude modulation (SAM) is proposed as an alternative to spatial phase modulation (SPM) techniques currently employed in most ultrasonic imaging systems. A simple implementation of a SAM-based imaging system using an optoacoustic transducer (OAT) is presented.


Title Focusing of therapeutic ultrasound through a human skull: A numerical study.
Author Sun J, Hynynen K.
Journal J Acoust Soc Am
Volume
Year 1998
Abstract A numerical model was developed which can use digitized layer interfaces to calculate ultrasound wave absorption, diffraction, reflection, and refraction. This model was used to evaluate the feasibility of ultrasound therapy and surgery through a human skull. A digitized human skull profile was obtained from magnetic resonance (MR) images and used to calculate the ultrasound field in the brain of a volunteer from a spherically curved phased array. With no phase correction, the focus of the array was shifted and defocused. The phased array technique was used to correct focal shift, reduce side lobes, and enhance focal amplitude. The optimum source element width was estimated for each frequency to obtain a near optimium focus, and an appropriate frequency range for transskull ultrasound therapy and surgery was determined. Acoustic pressure amplitude on the skull surfaces was examined, and it was shown that the skull heating problem could be overcome. Despite high attenuation, complex interface shape, and nonuniform thickness of a human skull, a sharply focused transskull ultrasound field can be generated for noninvasive ultrasound therapy and surgery in the brain.


Title Focussing ultrasound over a large depth with an annular transducer - An alternative method.
Author Burckhardt CB, Grandchamp PA, Hoffmann H.
Journal IEEE Trans Sonics Ultrason
Volume
Year 1975
Abstract An alternative method is described for focussing ultrasound over a large depth. The method is useful in B-scan. The final echo signal is obtained as the sum of two partial echo signals and different segments of an annular transducer are used for transmission and reception of the two partial echo signals. The advantages with respect to a method described previously are simplicity and a higher dynamic range. A lateral resolution of 2 mm is obtained which is almost an order of magnitude better than conventional B-scan. Scans of fetuses in virto are shown.


Title Foetal cephalometry by ultrasound.
Author Willocks J, Donald I, Duggan TC, Day N.
Journal J Obstet Gynaecol Br Commonw
Volume
Year 1965
Abstract To ascertain the size and to observe the growth of the foetus in utero are matters of great importance to the obstetrician, yet the methods hitherto available have been either imprecise or of limited application. Practically the only part of the foetus which can be measured is the head; this measurement has been made by X-rays with varying reliability. The use of the ultrasonic echo-sounding technique described here has, we believe, advantages over radiography.


Title Food and Drug Administration ultrasound device regulation: the output display standard, the mechanical index," and ultrasound safety.
Author Meltzer RS.
Journal J Am Soc Echocardiogr
Volume
Year 1996
Abstract The Food and Drug Administration has recently revised its guidelines regarding.acoustic output on diagnostic ultrasound equipment to allow a new track for.manufacturers to achieve approval to market diagnostic ultrasound equipment. It.would move for the first time toward regulating instrumental output based on.scientific bioeffect data. It would allow increased instrumental output in certain.modes and at the same time mandate on-screen labeling of a "thermal index" or."mechanical index," coupled with a user education program on the significance.of these indexes. The increased instrumental output allowed by these new.guidelines may benefit adult echocardiography by allowing slightly more.penetration and higher frequency/better resolution. However, a tradeoff is that.echocardiographers need to understand more about how to perform an.examination to decrease unnecessary patient exposure to ultrasound and more.about ultrasound bioeffects, such as the theoretical potential for cavitation-related.adverse effects in certain circumstances. ..


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