Bioacoustics Research Lab
University of Illinois at Urbana-Champaign | Department of Electrical and Computer Engineering | Department of Bioengineering
Department of Statistics | Coordinated Science Laboratory | Beckman Institute | Food Science and Human Nutrition | Division of Nutritional Sciences | College of Engineering
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William D. O'Brien, Jr. publications:

Michael L. Oelze publications:

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Your search for ultrasound produced 3296 results.

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Title Histological study of changes produced by ultrasound in the gray and white matter of the central nervous system.
Author Fry WJ, Brennan JF, Barnard JW.
Journal Ultrasound Med Biol
Volume
Year 1957
Abstract The purpose of the study reported in this paper was the determination of the ultrasonic dosage conditions required to produce very small white and gray matter lesions of different degrees of selectivity with respect to the various tissue components of the brain. Usually more than one position was irradiated in the brain of each animal, but the separate positions were spaced five to ten millimeters apart to permit observation of each site uninfluenced by the other lesions. This procedure is in contrast to our previously reported work on white matter lesions of a variety of shapes and sizes produced by irradiating the brain in a relatively large number of overlapping positions. Previous publications from this laboratory have described the design of the ultrasonic transducer employed, the thermocouple probe developed for accurate calibration of the acoustic field, and the experimental procedure used for surgical preparation and irradiation of the animals (Fry et al., 1954; Fry and Fry, 1954; Barnard et al., 1955; Fry et all., 1955a; Fry et al., 1955b).


Title Histomorphologic features of ultrasonic renal injury.
Author Elbadawi A, Linke CA, Carstensen EL, Fridd CW.
Journal Arch Pathol Lab Med
Volume
Year 1976
Abstract Fifteen-second exposure of rabbit kidneys to 2 MHz focused ultrasound with approximately 900 w/sq cm acoustic power consistently produced localized parenchymal destruction. Evolution of the lesions was followed histologically over a.one-year period. The lesions were sharply delineated from outlying renal tissue and had a concentric multizonal structure. Resorption of the damaged tissue with scarring was completed in 6 to 12 months following intermediate phases.characterized by cellular infiltration. The lesions are compared to other models of renal injury, particularly with respect to cellular infiltration. A combination of mechanical, thermal, and ischemic factors seem to be responsible for development of ultrasonic lesions. The sharply circumscribed nature and ultimate complete scarring of the lesions suggest the feasibility of ultrasound in achieving selective complete destruction of renal parenchyma.


Title Histopathological changes in the adrenals of rabbits after direct action of ultrasound on the brain.
Author Jankowiak J, Majewski C, Kubiak E.
Journal Am J Phys Med
Volume
Year 1963
Abstract The effect of ultrasonic irradiation on organs of laboratory animals under direct ultrasonic radiation has been described previously (1-10). In the present study, we have investigated the effect of ultrasonic irradiation of the brain on the adrenal gland. It was thought that the action of ultrasound on the brain might result in hormonal disorders of the pituitary adrenal system. It would therefore be important to investigate whether histological lesions could be found in the adrenals as an indirect result of ultrasonic radiation of the cerebrum. Such studies might indicate an indirect effect of ultrasound on hormonal coordination.


Title Histopathology of shock wave treated tumor cell.suspensions and multicell tumor spheroids.
Author Brauner T, Brummer F, Hulser DF
Journal Ultrasound Med Biol
Volume
Year 1989
Abstract L1210 mouse leukemia cell suspensions exposed to 500 shock waves (SW) in an.experimental lithotripter (XL1, Dornier) revealed severe cellular damage. Apart from.cell fragments and cellular debris, cells exhibited alterations of shape, vacuolization of.the cytoplasm, perinuclear cisternae, swelling of mitochondria or rupture of the.mitochondrial fine structure, and permeabilization of the cell membrane. Treatment of.multicell tumor spheroids of both HeLa and EMT6/Ro cells in suspension with 500.SW resulted either in loss of peripheral cells and serious cellular damage in the outer.regions or in a fragmentation of the spheroids. Many of the geometrically intact cells.exhibited the same histopathological alterations as the suspended L1210 cells..Immobilization of the spheroids in agar or gelatine, however, prevented spheroids.from being agitated and accelerated during SW-exposure. After treatment with 500.SW, spheroids immobilized in gelatine were not different from control cultures, as.investigated with light- and electronmicroscopy. From our results we conclude that.spheroids in suspension are subject to cavitation and liquid jet formation, causing not.only acceleration and shearing forces but also collisions which account for the.observed cell damage.


Title Hot spots created at skin-air interfaces during ultrasound hyperthermia.
Author Hynynen K.
Journal Int J Hyperthermia
Volume
Year 1990
Abstract It is well known that ultrasound beams will be completely reflected at a soft-tissue-gas interface. The reflected beam is contributing to the power absorption at the tissue interface and may cause a hot spot which could prevent therapeutic temperatures at the treatment volume. In this study the temperature elevation caused by a reflected ultrasound beam at the skin surface has been investigated in dogs' thighs in vivo. The magnitude of the hot spot was quantified and the effect of entrance angle was also investigated. In addition, the possibility of eliminating the hot spot by coupling the beam out of the tissue was studied. The results showed that the temperature elevation can be up to four times larger at the skin-air surface than in resting muscle under similar exposure. The geometry of the reflecting surface had a significant effect on the temperature distribution. When the sound was coupled out of the tissue the magnitude of the temperature elevation at the skin reduced to less than half (depending on the geometry) but was still larger than temperatures measured in muscle. These results suggest the need for computerized treatment planning for scanned focused ultrasound treatments.


Title How reliable are manufacturer's reported acoustic output data?
Author Jago JR, Henderson J, Whittingham TA, Willson K.
Journal Ultrasound Med Biol
Volume
Year 1995
Abstract No abstract available. Leeter to the editor-in-chief.


Title Human cancer treatment with ultrasound.
Author Corry PM, Jabboury K, Armour EP, Kong J.
Journal IEEE J Sonics Ultrason
Volume
Year 1984
Abstract Despite the interest in hyperthermia and the rather significant advantages that ultrasound possesses over other methods for localized heating, there remain only a few reports of human studies with well documented thermal dosimetry that permit the evaluation of the antitumor efficacy of ultrasound treatment. These reports are discussed, and the biological basis for the application of ultrasound hyperthermia as an antitumor modality is presented. Further, clinical results involving the application of ultrasonic huperthermia alone, and in conjuction with chemotherapy and radiation in 215 patients are reported. Overall objective response rates for ultrasound alone, ultrasound with chemotherapy, and ultrasound with radiation therapy were 45 percent, 60 percent, and 66 percent, respectively. Of particular encouragement was the treatment of advanced primary breast cancer with ultrasound combined with chemotherapy, where the first seven cases exhibited a 100 percent overall response rate to therapy.


Title Human fetal diagnostic ultrasound exposimetry system.
Author Swiney D, O'Brien WD Jr.
Journal Proc Ultrason Symp IEEE
Volume
Year 1996
Abstract Significant improvements have been made to a unique human fetal diagnostic ultrasound exposimetry system which has been designed to measure acoustic pressure in situ with a 7-element linear array hydrophone during an obstetric ultrasound examination. The purpose of the exposimetry system is to develop a data base of fundamental ultrasound propagation properties for human tissue under in vivo conditions from which the ultrasound exposure, and possibly the ultrasound dose, can be estimated under normal clinical conditions. The basic system design allows for the obstetrician to record calibrated acoustic pressure waveforms in situ that have propagated through tissue layers under conditions in which both the diagnostic ultrasound transducer and the calibrated hydrophone are hand-held. The improvements have increased the reliability of the recorded acoustic pressure waveform and provided the new capability of recording the image from the diagnostic ultrasound system simultaneously with the acoustic pressure waveform. The RF acoustic pressure waveforms are digitized at 50 MHz and displayed on a monitor to provide direct visual feedback to the obstetrician. The recorded acoustic pressure waveform is based on a two-decision process. First, the pulse intensity integral (PII), a measure of energy in the pulse, is calculated for each acquired waveform and subsequent recorded waveforms must have a greater PII. Second, a correlation coefficient is calculated for each acquired waveform and must exceed a predetermined correlation coefficient to be recorded. At the same time an RF pressure waveform is acquired, the exposimetry system digitally records the image from the diagnostic ultrasound scanner. This image shows the location of the hydrophone and provides the basis for estimating the types and distances of tissue layers between the diagnostic ultrasound scanner and the hydrophone, thus providing a direct tie between the acoustic propagation path and the recorded calibrated waveform.


Title Human in situ dosimetry: Differential insertion loss during passage through abdominal wall and myometrium.
Author Siddiqi TA, O'Brien WD Jr, Meyer RA, Sullivan JM, Miodovnik M.
Journal Ultrasound Med Biol
Volume
Year 1992
Abstract We constructed a specialized in vivo exposimetry system and determined selected ultrasonic field quantities. We examined two groups of non-pregnant women (nulliparas = 14, MULTIPARAS = 9) under conditions of full and empty bladder. A calibrated 7-element linear array hydrophone was placed in the anterior fornix of the vagina in each subject. In the full bladder condition, the sound beam traversed the anterior abdominal wall and full bladder, whereas after voiding, the sound beam traversed the abdominal wall and anteverted uterine fundus. Each study was conducted using a 3.5 MHz mechanical sector transducer. Calibration data were recorded after completion of each in vivo experiment. Data from both groups were pooled for analysis. Assuming (1) the sound path through the full bladder is loss less, the insertion loss (ILFULL) should represent the insertion loss for the abdominal wall (ILABD WALL) 8.2 ± 5.6 dB; whereas (2) for the empty bladder condition, (ILEMPTY) represents (ILABD WALL + ILUTERUS). Subtracting ILFULL from ILEMPTY yields ILUTERUS = 5.8 ± 6.8 dB. Therefore, knowing the respective path lengths and normalizing for frequency, the mean tissue attenuation coefficients (A) are estimated to be ILABD WALL = 1.39 dB/cm-MHz and AUTERUS = 0.14 dB/cm-MHz. These attenuation data suggest that the abdominal wall is the principal source of ultrasonic energy loss.


Title Human pharmacokinetics and safety evaluation of SonoVue, a new contrast agent for ultrasound imaging.
Author Morel DR, Schwieger I, Hohn L, Terrettaz J, Llull JB, Cornioley YA, Schneider M.
Journal Invest Radiol
Volume
Year 2000
Abstract RATIONALE AND OBJECTIVES: To assess in humans the pharmacokinetics of SonoVue, a new echo contrast agent based on stabilized sulfur hexafluoride (SF6) microbubbles and to provide additional safety and tolerability information on the compound. METHODS: The blood kinetics and pulmonary elimination of SF6 after intravenous bolus injection of two dosage levels (0.03 and 0.3 mL/kg) of SonoVue were evaluated in 12 healthy subjects (7 men, 5 women). In addition, safety and tolerability were evaluated by monitoring vital signs, adverse effects, discomfort, and physical examination and laboratory parameters associated with the SonoVue injection. RESULTS: The blood kinetics of SF6 was not dose dependent. SF6 was rapidly removed from the blood by the pulmonary route, with 40% to 50% of the injected dose eliminated within the first minute after administration and 80% to 90% eliminated by 11 minutes after administration; the elimination was similar in men and women and independent of dose. Both dosages were well tolerated. No adverse effects were observed immediately or during the 24-hour follow-up period. CONCLUSIONS: SonoVue was shown to be rapidly removed from the blood. The route of SF6 elimination was by means of the lungs in the expired air. SonoVue appeared to be safe and well tolerated in healthy subjects.


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