Bioacoustics Research Lab
University of Illinois at Urbana-Champaign | Department of Electrical and Computer Engineering | Department of Bioengineering
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Title The effect of ultrasound in a chemotherapeutic study of ascites tumor cells.
Author Kryszczuk MD.
Journal Thesis(PhD): Catholic Univ of America
Volume
Year 1962
Abstract No Abstract Available.


Title The effect of ultrasound in a chemotherapeutic study of ascites tumor cells.
Author Kryszczuk MD.
Journal Thesis(PhD): Catholic Univ of America
Volume
Year 1962
Abstract The effect of ultrasonic irradiation of living organisms,biological systems,tissues and cells is presently being studied in several countries. Recent literature indicates that there is a variety of approaches in the use of ultrasound in physiological studies.El'piner et al (1960) found that irradiation of ribonuclease resulted in considerable chemical transformation of the protein molecule; that it aided in the synthesis of amino acids,and that it produced oxidation of biological substances.The influence of ultrasonic irradiation on metabolism is reported as follows: Urbanowiez,Józkiewicz and Grabecki(1960) and Józkiewicz and Urbanowiez(1960) noted an accumulation of organic posphatesin the blood serum of guinea pigs;Stefanović Djukanowić , Velasević and Zivanović (1960) reported a decrease in the enzymatic activities of diastase;Elbowicz-Waniewska and Józkiewicz (1960) found an inhibition in the formation of the murexide-calcium ion complex. Therapeutic application producing analgesic effects was reported by Tsumuraya and Ariga (1959), and Ariga and Kabayashi (1959) studied the heating effects of ultrasonics on tissues in order to determine the mechanism of ultrasonic action in therapy.Tamas and bonto (1960) used ultrasonic radiation in permeability studies and found an increase in the diffusion coefficient of rhodonate ions into muscles. By the use of artificial and macroscopic membranes,Bálent and Nagy(1961) have demonstrated that changes in electricity conductivity of the membranes are closely related to the duration of the administered ultrasound,its intensity and the temperature.


Title The effect of ultrasound on conduction velocity of peripheral nerve.
Author Madsen PW Jr, Gersten JW.
Journal Arch Phys Med Rehabil
Volume
Year 1961
Abstract The purpose of this study was to extend the information concerning the effects of ultrasound on human nerve in situations comparable to those in common clinical use. Changes in temperature of subcutaneous tissue and in conduction velocity of the ulnar nerve following exposure to ultrasound were investigated. The ulnar nerve region, in the forearm, was sounded in the normal human subject. Conduction velocity in the ulnar nerve and temperature of subcutaneous tissue were measured. When ?sounding: was done without energy emission, both temperature and conduction velocity decreased. Conduction velocity decreased even at intensities of 0.88 and 1.28 watts/cm(2). With an intensity of 1.92 watts/cm(2), there was a relatively small increase in temperature (0.5 degrees C.) and in conduction velocity (0.8 percent). At intensities higher than this the temperature rise was smaller. If the area covered by the sound head was decreased the temperature rise and increase in conduction velocity were proportionately increased.


Title The effect of ultrasound on human chromosomes in vitro.
Author Rott HD, Soldner R.
Journal Humangenetik
Volume
Year 1973
Abstract No abstract available.


Title The effect of ultrasound on isolated nerve.
Author Vanhee FR.
Journal Thesis(MS): Catholic Univ of America
Volume
Year 1965
Abstract No abstract available.


Title The effect of ultrasound on microvascular hemodynamics in skeletal muscle: Effect on arterioles.
Author Hogan RD, Franklin TD, Fry FJ, Avery KS, Burke KM.
Journal Ultrasound Med Biol
Volume
Year 1982
Abstract A skeletal muscle model (rat cremaster muscle) has been described for the evaluation of ultrasonic bioeffects on the microscopic vasculature. One MHz pulsed ultrasound (mark-space 100μsec:100μsec) was administered to the tissue at 1.25, 2.5, 5.0 and 10.0Wcm−2 (temporal average) while continuously measuring lumen diameter, volume flow, and rate of vasomotion (intrinsic cyclic constriction and relaxation) in three different sizes of arterioles (100, 50, 30μm inner diameter). No change in these parameters was noted at intensities below 5Wcm−2. Above 5Wcm−2 there was a 25% decrease in diameter and a 44% decrease in volume flow in the smallest arterioles observed, as well as a 29% decrease in flow in the largest arteriole feeding the tissue. The rate of vasomotion in the smallest arterioles increased 20x in the same intensity range. None of these effects or their magnitude could be attributed to simple tissue heating in the same temperature range (34–36.5°C) as obtained with ultrasound exposures.


Title The effect of ultrasound on microvascular hemodynamics in.skeletal muscle: effects during ischemia.
Author Hogan RD, Burke KM, Franklin TD.
Journal Microvasc Res
Volume
Year 1982
Abstract To investigate the hypothesis that ultrasound can increase blood flow in ischemic tissues, the rat cremaster muscle was exposed to 1 MHz pulsed sound at intensities in the range 1.25 to 10.0 W/cm2 (temporal average-spatial peak). A previous study has shown that small arterioles (lumen diameter < 30 ?m) constrict as much as 25% in normal muscle when insonated, associated with a 45% decrease in single-vessel blood flow. In the present study, when perfusion pressure to the cremaster muscle was reduced acutely to 40 mm Hg by aortic occlusion, the arterioles still constricted by 10-15% in response to insonation, but with no measurable reduction in blood flow. In a second set of studies, the cremaster muscle was made chronically ischemic by ligation of the main arterial branch supplying the muscle. Insonation for 5 min at 2.5 W/cm2 on alternate days for either 1 or 3 weeks improved blood flow in the midsized arterioles (lumen diameter ~ 50 ?m) such that it was not significantly different from normal. This was primarily associated with increased capillary density in the insonated muscle compared to that in the noninsonated muscle. We conclude that insonation of skeletal muscle transiently constricts the small arterioles, but that long-term treatment can improve perfusion in vascularly impaired muscle.


Title The effect of ultrasound on the hyperthermic response of mammalian cells in vitro: a preliminary report.
Author ter Haar G, Stratford IJ.
Journal Proc First Meet Eur Group Hyperthermia Radiat Oncol
Volume
Year 1979
Abstract The recent interest in ultrasound as a potential heating agent in the hyperthermic treatment of cancer, has meant that it has become necessary to understand the way in which ultrasound interacts with tissue at the cellular level. This paper describes experiments designed to elucidate the way in which ultrasound enhances the hyperthermic killing of cells. In experiments with cells labelled with 5-BUdR, it is shown that ultrasonic irradiation (3 MHz, 3W/cm2 continuous wave) does not cause DNA damage. It is shown that the ultrasonic enhancement of killing of heated cells is present for cells in exponential growth, and also that it is more marked when cells are in a medium of pH 6.8 than of pH 7.4.


Title The effect of ultrasound on the in vitro penetration of ibuprofen through human epidermis.
Author Brucks R, Nanavaty M, Jung D, Siegel F.
Journal Pharm Res
Volume
Year 1989
Abstract The objective of this study was to develop an in vitro method to investigate the effect of ultrasound on the in vitro absorption of ibuprofen from a propylene glycol/water vehicle through human epidermis. A diffusion cell was modified so ultrasound could be applied to the vehicle and skin. Since ultrasound can increase the temperature underneath the area of application, control representing temperature effects ran concurrently to the ultrasound experiment. The results demonstrate that ultrasound can increase the penetration of ibuprofen through human skin. This increase in diffusion was greater than for controls where an equivalent increase in temperature was utilized. The results also indicate that evaporation of vehicle components may alter the skin/vehicle partition coefficient, decreasing the effects of ultrasound on the penetration of ibuprofen through the skin.


Title The effect of ultrasound on the permeability of Krebs-2 mouse ascites cells to chromium 51 (Cr51).
Author Comiskey JK.
Journal Thesis(MS): Catholic Univ of America
Volume
Year 1961
Abstract No abstract available.


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