Kullervo Hynynen, Ph. D.
Brigham and Women's Hospital, Harvard Medical School
Focused ultrasound can be used for noninvasive thermal
coagulation of tumors. However, the previous studies have
shown that there is significant variability in the coagulated
tissue volumes when the system is used in an open-loop manner.
Therefore it has been difficult to predict the actual
temperature elevation and thus, the thermal exposure during
the treatments. Magnetic Resonance Imaging (MRI) guided
ultrasound surgery systems have been developed in order
to minimize this variability and to assure complete tissue
coagulation in the target volume. Experiments and early
clinical trials have shown that the MRI thermometry can
provide adequate feedback to assure correct target location
and to assure adequate thermal exposure. This system is
currently undergoing clinical testing in three institutions
for noninvasive breast cancer treatments.
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